Lifespan : Why We Age—and Why We Don't Have To

作者：DavidA.Sinclair,MatthewD.LaPlante

出版社：AtriaBooks

副标题：WhyWeAge—andWhyWeDon'tHaveTo

出版年：2019-9-10

页数：432

定价：USD14.99

装帧：平装

ISBN：9781501191978

内容简介
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From an acclaimed Harvard professor and one of Time’s most influential people, this paradigm-shifting book shows how almost everything we think we know about aging is wrong, offers a front-row seat to the amazing global effort to slow, stop, and reverse aging, and calls readers to consider a future where aging can be treated. For decades, experts have believed that we are at the mercy of our genes, and that natural damage to our genes—the kind that inevitably happens as we get older—makes us become sick and grow old. But what if everything you think you know about aging is wrong? What if aging is a disease—and that disease is treatable? In Lifespan, one of the world’s foremost experts on aging and genetics reveals a groundbreaking new theory that will forever change the way we think about why we age and what we can do about it. Aging isn’t immutable; we can have far more control over it than we realize. This eye-opening and provocative work takes us to the frontlines of research that is pushing the boundaries on our perceived scientific limitations, revealing incredible breakthroughs—many from Dr. David Sinclair’s own lab—that demonstrate how we can slow down, or even reverse, the genetic clock. The key is activating newly discovered vitality genes—the decedents of an ancient survival circuit that is both the cause of aging and the key to reversing it. Dr. Sinclair shares the emerging technologies and simple lifestyle changes—such as intermittent fasting, cold exposure, and exercising with the right intensity—that have been shown to help lead to longer lives. Lifespan provides a roadmap for taking charge of our own health destiny and a bold new vision for the future when humankind is able to live to be 100 years young.

作者简介
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David Sinclair, PhD, AO is a professor of genetics at Harvard Medical School. One of the leading innovators of his generation, he has been named by Time as “one of the 100 most influential people in the world” and top 50 most influential people in healthcare. He is a board member of the American Federation for Aging Research and has received more than 35 awards for his research and major scientific breakthroughs. Dr. Sinclair and his work have been featured on 60 Minutes, Today, The Wall Street Journal, The New York Times, Fortune, and Newsweek, among others. He lives in Boston and enjoys hiking and kayaking with his wife and three children. To learn more, visit LifespanBook.com and follow him on Twitter @DavidASinclair.

Matthew LaPlante is an associate professor of journalistic writing at Utah State University, where he teaches news reporting and feature writing. A former US Navy intelligence specialist and Middle East war correspondent, he is the author of Superlative: The Biology of Extremes and the cowriter of multiple other books on the intersection of science and society. He lives in Salt Lake City and skis in Big Cottonwood Canyon. To learn more, visit MDLaPlante.com and follow him on Twitter @MDLaPlante.

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目录
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Introduction: A Grandmother’s Prayer

PART I: WHAT WE KNOW (THE PAST)

1. Viva Primordium

2. The Demented Pianist

3. The Blind Epidemic

PART II: WHAT WE’RE LEARNING (THE PRESENT)

4. Longevity Now

5. A Better Pill to Swallow

6. Big Steps Ahead

7. The Age of Innovation

PART III: WHERE WE’RE GOING (THE FUTURE)

8. The Shape of Things to Come

9. A Path Forward

Conclusion

Acknowledgement

Notes

Sinclair Disclosure

The Scale of Things

Cast of Characters

Glossary

Index

评论 ······

大学同学因为个人原因天天来我家吃3顿饭 不好意思白吃 送了我一些书..这书一看就是瞎拼凑的..作者是NMN教主啊..还让绝经妇女重新例假的神棍..还很厚脸皮说自己40岁就放弃了甜品..我心想..都吃了40年了的sweets你抗衰老？还神神叨叨列举了自己的regimen心得..说他本人和家人和实验室的做法都是如此..inform下读者..看到笑死..本韭菜打小就那样做的啊..都是基于常识的选择..作…

fasting，定期禁食一下下；运动，特别是 High Intensity Interval Training (HIIT)，和 diet 甚至 fasting 结合；时不时让自己受冻一下，也是不是让自己热一下（比如蒸桑拿）。总之就是时不时让自己有点危机感，多激活一下体内在远古时代还是单细胞的时候就进化出来的遗传信息自检、查错和修复机制。

Youth → broken DNA → genome instability → disruption of DNA packaging and gene regulation (the epigenome) → loss of cell identity → cellular senescence → disease → death

长寿的三个秘诀：适度可控的饥饿，寒冷和高强度运动

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